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Energy and Environment Directorate

Karthi Ramasamy

Karthi Ramasamy

Pacific Northwest National Laboratory
PO Box 999
Richland, WA 99352
(509) 372-6976


Karthikeyan K. Ramasamy received his B. Eng. degree from Bharathiar University, India, M.S degree from University of Central Florida, Orlando, FL and Ph. D degree from Washington State University, Pullman, WA under the supervision of Yong Wang. Prior to joining PNNL Dr. Ramasamy worked as a Research Engineer at Florida Solar Energy Center, Cocoa, FL between 2002 to 2008. During this period, he was involved in research focused on renewable hydrogen production and hydrogen storage. Dr. Ramasamy is currently a Chief Chemical Engineer at PNNL. His current research work is focused on developing heterogeneous catalyst towards producing renewable chemicals, marine fuels and sustainable aviation fuels.

Research Interests

  • Heterogeneous catalyst development
  • Green chemistry development towards renewable chemicals
  • Chemical process development
  • Sustainable aviation fuels and marine fuels

Education and Credentials

  • Ph.D., Chemical Engineering, Washington State University
  • M.S., Environmental Engineering, University of Central Florida
  • B.S., Chemical Engineering, Bharathiar University, India

Affiliations and Professional Service

  • Alternate Councilor, American Chemical Society, Catalysis Science & Technology Division (2022-Present)
  • Director, American Institute of Chemical Engineers, Fuels & Petrochemical Division (2020-Present)
  • Co-Chair, Hydrothermal Liquefaction: Path to Sustainable Aviation Fuel Workshop (2020)
  • Co-Chair, Thermal and Catalytic Sciences for Biofuels and Biobased Products Conference (2020)
  • Editorial Advisory Board, Catalysis Today (2018-Present)
  • Treasurer, American Chemical Society, Catalysis Science & Technology Division (2018-2021)
  • Program Chair, American Chemical Society, Catalysis Science & Technology Division (2014-2017)
  • Member of the American Chemical Society (ACS)
  • Member of the American Institute of Chemical Engineers (AIChE)

PNNL Patents

PNNL Publications


  • Kallupalayam Ramasamy K. 2024. Demonstrate the Catalytic Conversion Fermentation Derived Intermediate to Isoprene - CRADA 365 (Abstract). PNNL-35282. Richland, WA: Pacific Northwest National Laboratory.
  • Kallupalayam Ramasamy K. 2024. Terephthalic Acid Synthesis from Ethanol via p-Methyl Benzaldehyde - CRADA 395 (Abstract). PNNL-35290. Richland, WA: Pacific Northwest National Laboratory.


  • Kallupalayam Ramasamy K., M.F. Guo, U. Sanyal, and L. Meyer. 2023. Mixed Oxygenate Conversion to Sustainable Aviation Fuel via Ketones Intermediate. PNNL-34857. Richland, WA: Pacific Northwest National Laboratory. Mixed Oxygenate Conversion to Sustainable Aviation Fuel via Ketones Intermediate
  • Kilgore U.J., D.M. Santosa, S. Li, P. Wang, S. Lee, M.R. Thorson, and K. Kallupalayam Ramasamy. 2023. "Desalting Biocrude for Improved Downstream Processing toward Marine Fuel Application." Sustainable Energy & Fuels 7, no. 11:2670-2679. PNNL-SA-181968. doi:10.1039/D3SE00189J
  • Kilgore U.J., S. Subramaniam, S.P. Fox, D.J. Cronin, M.F. Guo, A.J. Schmidt, and K. Kallupalayam Ramasamy, et al. 2023. "Wet air oxidation of HTL aqueous waste." Biomass & Bioenergy 176. PNNL-SA-175978. doi:10.1016/j.biombioe.2023.106889
  • Masum F., G. Zaimes, E. Tan, S. Li, A. Dutta, K. Kallupalayam Ramasamy, and T.R. Hawkins. 2023. "Comparing Life-Cycle Emissions of Biofuels for Marine Applications: Hydrothermal Liquefaction of Wet Wastes, Pyrolysis of Wood, Fischer-Tropsch Synthesis of Landfill Gas, and Solvolysis of Wood." Environmental Science & Technology 57, no. 34:12701-12712. PNNL-SA-185362. doi:10.1021/acs.est.3c00388
  • Seiple T.E., Y. Jiang, L.J. Snowden-Swan, N.J. Betzsold, K. Kallupalayam Ramasamy, and C. Fuller. 2023. "Cost-effective Opportunities to Produce Sustainable Aviation Fuel from Low-Cost Wastes in the U.S." ACS Sustainable Chemistry & Engineering 11, no. 33:12326-12335. PNNL-SA-188095. doi:10.1021/acssuschemeng.3c02147


  • Cronin D.J., S. Subramaniam, C.O. Brady, A.R. Cooper, Z. Yang, J.S. Heyne, and C. Drennan, et al. 2022. "Sustainable Aviation Fuel from Hydrothermal Liquefaction of Wet-Wastes." Energies 15, no. 4:Art. No. 1306. PNNL-SA-169987. doi:10.3390/en15041306
  • Kallupalayam Ramasamy K., and M.F. Guo. 2022. Ethanol to Para-xylene via Methyl Benzaldehyde. PNNL-32862. Richland, WA: Pacific Northwest National Laboratory. Ethanol to Para-xylene via Methyl Benzaldehyde
  • Li S., E. Tan, A. Dutta, L.J. Snowden-Swan, M.R. Thorson, K. Kallupalayam Ramasamy, and A. Bartling, et al. 2022. "Techno-economic Analysis of Sustainable Biofuels for Marine Transportation." Environment Science and Technology 56, no. 23:17206-17214. PNNL-SA-173450. doi:10.1021/acs.est.2c03960
  • Lin F., M. Xu, K. Kallupalayam Ramasamy, Z. Li, J. Klinger, J. Schaidle, and H. Wang. 2022. "Catalyst Deactivation and its Mitigation during Catalytic Conversions of Biomass." ACS Catalysis 12, no. 21:13555-13599. PNNL-SA-175764. doi:10.1021/acscatal.2c02074
  • Snowden-Swan L.J., S. Li, Y. Jiang, M.R. Thorson, A.J. Schmidt, T.E. Seiple, and J.M. Billing, et al. 2022. Wet Waste Hydrothermal Liquefaction and Biocrude Upgrading to Hydrocarbon Fuels: 2021 State of Technology. PNNL-32731. Richland, WA: Pacific Northwest National Laboratory. doi:10.2172/1863608.Wet Waste Hydrothermal Liquefaction and Biocrude Upgrading to Hydrocarbon Fuels: 2021 State of Technology


  • Cosimbescu L., K.B. Campbell, S. Subramaniam, M.S. Swita, N. Hao, C.M. Moore, and K. Kallupalayam Ramasamy, et al. 2021. "The Properties of Bicyclic and Multicyclic Hydrocarbons as Bio-derived Compression Ignition Fuels That Can Be Prepared via Efficient and Scalable Routes from Biomass." Sustainable Energy & Fuels 5, no. 12:3143-3159. PNNL-SA-156518. doi:10.1039/d0se01742f
  • Guo M.F., M.J. Gray, H.M. Job, C.A. Alvarez-Vasco, S. Subramaniam, X. Zhang, and L. Kovarik, et al. 2021. "Uncovering the Active Sites and Demonstrating Stable Catalyst for Cost-Effective Conversion of Ethanol to 1-Butanol." Green Chemistry 23, no. 20:8030-8039. PNNL-SA-164007. doi:10.1039/D1GC01979A
  • Maddi B., S.D. Davidson, H.M. Job, R.A. Dagle, M.F. Guo, M.J. Gray, and K. Kallupalayam Ramasamy. 2021. "Production of Gaseous Olefins from Syngas over a Cobalt-HZSM-5 Catalyst." Catalysis Letters 151, no. 2:526-537. PNNL-SA-134786. doi:10.1007/s10562-020-03324-7
  • Subramaniam S., D.M. Santosa, C.O. Brady, M.S. Swita, K. Kallupalayam Ramasamy, and M.R. Thorson. 2021. "Extended catalyst lifetime testing for HTL biocrude hydrotreating to produce fuel blendstocks from wet wastes." ACS Sustainable Chemistry & Engineering 9, no. 38:12825-12832. PNNL-SA-161175. doi:10.1021/acssuschemeng.1c02743


  • Dagle R.A., A.D. Winkelman, K. Kallupalayam Ramasamy, V. Dagle, and R.S. Weber. 2020. "Ethanol as a renewable building block for fuels and chemicals." Industrial and Engineering Chemistry Research 59, no. 11:4843-4853. PNNL-SA-148314. doi:10.1021/acs.iecr.9b05729
  • Shi H., K. Kallupalayam Ramasamy, R. Ma, and H. Wang. 2020. "Nanoporous Catalysts for Biomass Conversion." In Nanoporous Materials for Molecule Separation and Conversion, edited by J. Liu and F. Ding. 387-440. PNNL-SA-152618. doi:10.1016/B978-0-12-818487-5.00012-1
  • Subramaniam S., M.F. Guo, T. Bathena, M.J. Gray, X. Zhang, A.I. Martinez, and L. Kovarik, et al. 2020. "Direct Catalytic Conversion of Ethanol to C5+ Ketones: Role of Pd-Zn Alloy on Catalytic Activity and Stability." Angewandte Chemie International Edition 59, no. 34:14550-14557. PNNL-SA-148910. doi:10.1002/anie.202005256
  • Weber R.S., and K. Kallupalayam Ramasamy. 2020. "Electrochemical Oxidation of Lignin and Waste Plastic." ACS Omega 5, no. 43:27735-27740. PNNL-SA-155219. doi:10.1021/acsomega.0c03989


  • Guo M.F., S. Subramaniam, M.J. Gray, and K. Kallupalayam Ramasamy. 2019. "Selective Butanol Production from Ethanol over an Atomically Dispersed Cu on Mixed Oxide Catalyst." In North American Catalysis Society Meeting (NAM 26), June 23-28, 2019, Chicago, IL. Orefield, Pennsylvania:North American Catalysis Society. PNNL-SA-140256.
  • Murugesan V., M.J. Gray, M.F. Guo, H.M. Job, L. Kovarik, A. Devaraj, and S. Thevuthasan, et al. 2019. "Thermally Activated Nucleation and Growth of Cobalt and Nickel Oxide Nanoparticles on Porous Silica." Journal of Vacuum Science & Technology A: International Journal Devoted to Vacuum, Surfaces, and Films 37, no. 3:Article No. 031101. PNNL-SA-121414. doi:10.1116/1.5080448
  • Settle A., N.S. Cleveland, C. Farberow, D. Conklin, X. Huo, A. Dameron, and R. Tracy, et al. 2019. "Enhanced Catalyst Durability for Bio-Based Adipic Acid Production by Atomic Layer Deposition." Joule 3, no. 9:2219-2240. PNNL-SA-144252. doi:10.1016/j.joule.2019.06.022
  • Su Q., H. Dai, H. Chen, Y. Lin, Y. Xie, and K. Kallupalayam Ramasamy. 2019. "General Equilibrium Analysis of the Cobenefits and Trade-Offs of Carbon Mitigation on Local Industrial Water Use and Pollutants Discharge in China." Environmental Science & Technology 53, no. 3:1715-1724. PNNL-SA-142640. doi:10.1021/acs.est.8b05763


  • Devaraj A., V. Murugesan, J. Bao, M.F. Guo, M.A. Derewinski, Z. Xu, and M.J. Gray, et al. 2017. "Nanoscale Compositional Mapping of Spent HZSM-5: An Atom Probe Tomography Study." In Proceedings of the North American Catalysis Society Meeting (NAM25), June 4-9, 2017, Denver, CO. PNNL-SA-122368.
  • Murugesan V., M.J. Gray, M.F. Guo, H.M. Job, A. Devaraj, C.J. Szymanski, and S. Thevuthasan, et al. 2017. "Thermal Evaluation of Metal Oxides on Silica Supports." In North American Catalysis Society Meeting, June 4-9, 2017, Denver, CO, Paper No. P-T-BRM-44. PNNL-SA-122369.


  • Alvarez-Vasco C.A., R. Ma, M. Quintero, M. Guo, S.C. Geleynse, K. Kallupalayam Ramasamy, and M.P. Wolcott, et al. 2016. "Unique Low-molecular-weight Lignin with High Purity Extracted from Wood by Deep Eutectic Solvents (DES): A Source of Lignin for Valorization." Green Chemistry 18, no. 19:5133-5141. PNNL-SA-118851. doi:10.1039/C6GC01007E
  • Devaraj A., V. Murugesan, J. Bao, M.F. Guo, M.A. Derewinski, Z. Xu, and M.J. Gray, et al. 2016. "Discerning the Location and Nature of Coke Deposition from Surface to Bulk of Spent Zeolite Catalysts." Scientific Reports 6. PNNL-SA-113562. doi:10.1038/srep37586
  • Lebarbier V.M., C.D. Smith, M.D. Flake, K.O. Albrecht, M.J. Gray, K.K. Ramasamy, and R.A. Dagle. 2016. "Integrated Process for the Catalytic Conversion of Biomass-Derived Syngas into Transportation Fuels." Green Chemistry 18, no. 7:1880-1891. PNNL-SA-113248. doi:10.1039/c5gc02298c
  • Ma R., M.F. Guo, K. Lin, V. Hebert, J. Zhang, M.P. Wolcott, and M. Quintero, et al. 2016. "Peracetic Acid Depolymerization of Biorefinery Lignin for Production of Selective Monomeric Phenolic Compounds." Chemistry - A European Journal 22, no. 31:10884-10891. PNNL-SA-117752. doi:10.1002/chem.201600546
  • Ramasamy K.K., M.J. Gray, H.M. Job, C.D. Smith, and Y. Wang. 2016. "Tunable catalytic properties of bi-functional mixed oxides in ethanol conversion to high value compounds." Catalysis Today 269. PNNL-SA-115950. doi:10.1016/j.cattod.2015.11.045
  • Ramasamy K.K., M.J. Gray, H.M. Job, D.M. Santosa, X.S. Li, A. Devaraj, and A.J. Karkamkar, et al. 2016. "Role of Calcination Temperature on the Hydrotalcite Derived MgO-Al2O3 in Converting Ethanol to Butanol." Topics in Catalysis 59, no. 1:46-54. PNNL-SA-110874. doi:10.1007/s11244-015-0504-8
  • Smith C.D., V.M. Lebarbier, M.D. Flake, K.K. Ramasamy, L. Kovarik, M.E. Bowden, and T. Onfroy, et al. 2016. "Conversion of Syngas-Derived C2+ Mixed Oxygenates to C3-C5 Olefins over ZnxZryOz Mixed Oxides Catalysts." Catalysis Today 6, no. 7:2325-2316. PNNL-SA-111860. doi:10.1039/C5CY01261A
  • Tan E., L.J. Snowden-Swan, M. Talmadge, A. Dutta, S.B. Jones, K. Kallupalayam Ramasamy, and M.J. Gray, et al. 2016. "Comparative Techno-economic Analysis and Process Design for Indirect Liquefaction Pathways to Distillate-range Fuels via Biomass-derived Oxygenated Intermediates Upgrading." Biofuels, Bioproducts & Biorefining 11, no. 1:41-66. PNNL-SA-120207. doi:10.1002/bbb.1710


  • Ramasamy K.K., M.J. Gray, H.M. Job, and Y. Wang. 2015. "Direct Syngas Hydrogenation over a Co-Ni Bimetallic Catalyst: Process Parameter Optimization." Chemical Engineering Science 135. PNNL-SA-107517. doi:10.1016/j.ces.2015.03.064


  • Ramasamy K.K., and Y. Wang. 2014. "Ethanol Conversion to Hydrocarbons on HZSM-5: Effect of Reaction Conditions and Si/Al Ratio on the Product Distributions." Catalysis Today 237. PNNL-SA-101512. doi:10.1016/j.cattod.2014.02.044
  • Ramasamy K.K., H. Zhang, J. Sun, and Y. Wang. 2014. "Conversion of Ethanol to Hydrocarbons on Hierarchical HZSM-5 Zeolites." Catalysis Today 238. PNNL-SA-100662. doi:10.1016/j.cattod.2014.01.037
  • Ramasamy K.K., M.A. Gerber, M.D. Flake, H. Zhang, and Y. Wang. 2014. "Conversion of Biomass-Derived Small Oxygenates over HZSM-5 and its Deactivation Mechanism." Green Chemistry 16, no. 2:748-760. PNNL-SA-97838. doi:10.1039/c3gc41369a


  • Ramasamy K.K., and Y. Wang. 2013. "Catalyst Activity Comparison of Alcohols over Zeolites." Journal of Energy Chemistry 22, no. 1:65-71. PNNL-SA-92939.
  • Ramasamy K.K., and Y. Wang. 2013. "Conversion of Methanol, Ethanol and Propanol over Zeolites." In 23rd North American Catalysis Society Meeting, June 2-7, 2013, Louisville, Kentucky, Paper No. P-Tu-BRC-67. N/A:North American Catalysis Society. PNNL-SA-92019.
  • Ramasamy K.K., and Y. Wang. 2013. "THERMOCHEMICAL CONVERSION OF FERMENTATION-DERIVED OXYGENATES TO FUELS." In Biomass Processing, Conversion and Biorefinery, edited by B Zhang and Y Wang. 289-300. Hauppauge, New York:Nova Publishers. PNNL-SA-92769.


  • Ramasamy K.K., M.A. Gerber, M.A. Lilga, and M.D. Flake. 2012. "Conversion of Mixed Oxygenates Generated from Synthesis Gas to Fuel Range Hydrocarbon." In 244th ACS National Meeting & Exposition, August 19-23, Philadelphia, Pennsylvania. Washington Dc:American Chemical Society. PNNL-SA-87111.


  • Lilga M.A., K.O. Albrecht, K.K. Ramasamy, T.L. Lemmon, L. He, H.M. Brown, and S. Lee, et al. 2010. CONVERSION OF LACTIC ACID TO ACRYLIC ACID AND ITS ESTER DERIVATIVES. PNNL-19802. Richland, WA: Pacific Northwest National Laboratory.

Energy and Environment

Core Research Areas